تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Computer modelling and simulations of thermotropic and lyotropic alkyl glycoside bilayers
Computer modelling and simulations of thermotropic and lyotropic alkyl glycoside bilayers
 
الموضوع : كيمياء 
لغة الوثيقة : الانجليزية 
المستخلص : Simulations on bilayers have previously proven their ability to provide insights to membrane functions such as fusion. Most simulations are based on the major components of cell membranes, which are phospholipids and cholesterol. Membranes can be explained on the basis of hydrophilic and hydrophobic interactions via hydrogen bonding, van der Waals interactions and repulsive forces. While particularly phospholipids have gained significant attention in bio-related modelling and simulations, glycolipids, which constitute another major component of cell membranes, have not been similarly studied. Here we present the simulation of bilayers for the six most common and simple stereoisomeric glycolipids, namely the α- and β-octyl glycosides of glucose, galactose and mannose, in both thermotropic and lyotropic systems. All these compounds form thermotropic smectic A phases and can exhibit lyotropic lamellar assemblies. We have studied the hydrogen bonding and linked the results to the temperature stability of the corresponding liquid crystal phase. In addition to the mesophase-stabilizing effect of hydrogen bonding in general, we found that the thermal stability appears to be particularly affected by intralayer hydrogen bonding. The simulations also confirmed a significant difference in the density of the lipophilic region for α- and β-glycosides, which has previously been used to explain differences in clearing temperatures. 
ردمد : 0267-8292 
اسم الدورية : Liquid Crystals 
المجلد : 34 
العدد : 3 
سنة النشر : 1428 هـ
2007 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, December 26, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Teoh Teow ChongChong, Teoh Teowباحثدكتوراه 
Thorsten HeidelbergHeidelberg, Thorsten باحثدكتوراه 
Rauzah HashimHashim, Rauzah باحثدكتوراهrauzah@um.edu.my
سعدالله قاري عزيزAziz, Saadullah Gباحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 31774.pdf pdfAbstract

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